Dr Manzini has had an illustrious career in the public service spanning over 33 years (1977 – 2010). Among other positions, Dr Manzini served as Head of Department: Health & Social Development (2002 – 2005) and Director-General: Limpopo Provincial Government (2005 – 2010), Facilitator: Provincial Directors General Forum (2007 – 2009). Dr Manzini is now retired but continues to assist the South African government with the implemetation of social infrastructure as a consultant for the Independent Development Trust.

Dr Manzini previously served as a director and/or trustee of numerous organisations in her personal capacity and as a government representative, including Lemana College of Education Council (1993 – 1996), Health Systems Trust (2000 – 2006), Oliver Tambo Fellowship Programme (2003 – 2006), South African Institute of Health Managers (2003 – 2006), BIOVAC Institute (2004 – 2006). Dr Manzini holds a D. Litt et Phil doctorate degree at UNISA (1997). She also studied the Senior Executive Programme at Wits and Harvard universities (2001) and the International Health Leadership Programme at Cambridge University.

Dr Manzini participated in study awards to numerous countries sponsored by various global organisations including the World Health Organisation (to Indonesia, 1994) and British Council to Oxford (to the United Kingdom). Dr Manzini has written and presented numerous published and unpublished research papers, mostly in relation to health matters.

Dr Manzini has been a member of many professional bodies and continues to serve in the follwing positions; Member of Valoyi Royal Family and Royal Council (2002 – Date) and the Chairperson of the Etna Trading Board (2011 – Date).